In a sermon on Romans 1:24-28, John Piper explains what humans are really up against:
The deepest problem of our lives, whether heterosexual or homosexual, is the terrible exchange of the glory of God for images (verse 23). The exchange of the truth of God for a lie (verse 25). The disapproval of having God in our knowledge (verse 28). Failed worship is our worst disorder. This is beneath all the maladies of the world. Repairing this, not first our disordered sexuality, is our main business in life.